John Pool - Publications
11. Rebeiz, M., J. E. Pool, V. Kaessner, C. F. Aquadro, and S. Carroll. 2009. Stepwise modification of a modular enhancer underlies local adaptation in a Drosophila population. Science, Accepted.
Identifies a combination of new mutations and standing variation at a cis-regulatory element of ebony that underlie adaptive changes in pigmentation.
10. Pool, J. E., I. Hellmann, J. D. Jensen, and R. Nielsen. 2009. Population genetic inference from genomic sequence variation. Invited review, submitted to Genome Research.
A review covering population genetic inference from genome-scale sequence data sets, with original analysis of long shared haplotypes in the human genome.
9. Pool, J. E. and R. Nielsen. 2009. Inference of historical changes in migration rate from the lengths of migrant tracts. Genetics 181:711-719. PDF
Introduces a method to test for migration rate changes from population genomic data, and applies this analysis to hybridizing house mouse subspecies.
8. Wang, J. et al. 2008. The diploid genome sequence of an Asian individual. Nature 456:60-65. PDF
The third human genome to be sequenced - allowing for population genetic analysis at the genomic level.
7. Pool, J. E. and R. Nielsen. 2008. The impact of founder events on chromosomal variability in multiply mating species. Mol. Biol. Evol. 25:1728-1736. PDF
Finds that founder events involving multiply mated females have strong effects on X-linked versus autosomal diversity, consistent with empirical data from D. melanogaster.
6. Pool, J. E. and R. Nielsen. 2007. Population size changes reshape genomic patterns of diversity. Evolution 62:3001-3006. PDF Correction (Selected for Faculty of 1000 Biology)
Clarifies the effects of population size changes on X-linked versus autosomal diversity, and finds evidence for this effect in empirical data sets.
5. Pool, J. E. and C. F. Aquadro. 2007. The genetic basis of adaptive pigmentation variation in Drosophila melanogaster. Molecular Ecology 16:2844-2851. PDF PDF2 PUBMED (“Fast Track” article, cover article, and subject of a “News and Views” article by M. Kohn and P. Wittkopp in the same issue)
Shows a strong link between melanic pigmentation and high altitude in African D. melanogaster, and evidence that adaptive changes at ebony contribute to this pattern.
4. Wong, A., J. D. Jensen, J. E. Pool, and C. F. Aquadro. 2007. Phylogenetics of the Drosophila melanogaster species group – evidence for ancestral lineage sorting and recombination. Mol. Phyl. Evol. 43:1138-1150. PDF PUBMED
One of a few studies that revised the previously accepted species tree of the D. melanogaster subgroup.
3. Pool, J. E. and C. F. Aquadro. 2006. History and structure of sub-Saharan populations of Drosophila melanogaster. Genetics 174:915-929. PDF
Found evidence for an East African origin of D. melanogaster, structure between East and West African populations, and a Nile route for the out-of-Africa expansion.
2. Pool, J. E., A. Wong, and C. F. Aquadro. 2006. Finding of male-killing Spiroplasma infecting Drosophila melanogaster in Africa implies transatlantic migration of this endosymbiont. Heredity 97:27-32. PDF
A male-killing bacterium infecting D. melanogaster within the fly's ancestral range.
1. Pool, J. E., V. Bauer DuMont, J. L. Mueller, and C. F. Aquadro. 2006. A scan of molecular variation leads to the narrow localization of a selective sweep affecting both Afrotropical and cosmopolitan populations of Drosophila melanogaster. Genetics 172:1093-1105. PDF
Variation scan of a non-candidate genomic region, and precise localization of a sweep that occurred in an ancestral population of D. melanogaster.