The Pool lab's research is in two related areas:
Basis of Adaptive Evolution
Drosophila melanogaster provides an excellent model system for learning about the genes and mutations that underpin adaptive phenotypic changes. Our ongoing work investigates the genetic basis of body size, cold tolerance, and pigmentation differences within this species. Each of these traits shows patterns of parallel evolution associated with high altitude.
|Analysis of Population
"Next-generation sequencing" has revolutionized our field by allowing us to study genetic variation at the scale of fully sequenced genomes. We develop new statistical methods for population genomics, and we analyze data to gain biological insights regarding the targets of natural selection and the histories of populations.